Medication possession ratio (MPR), dose reduction and dose omission rates in the first three months of taking abemaciclib were compared. Baseline characteristics of patients in each group were compared with t-tests for continuous data and the chi square test for categorical data. Patients who received welcome kits (each welcome kit contains three boxes, each box contains ten 2mg tablets of loperamide) served as the intervention group patients who did not receive welcome kits served as the standard of care group. Methods: This is a retrospective study of patients throughout the United States with HR+, HER2- breast cancer who received abemaciclib from a large specialty pharmacy from Jto December 31, 2019. The purpose of this study is to determine whether adherence to abemaciclib differs for patients who receive loperamide in welcome kits versus those who do not receive loperamide in welcome kits. While the adverse events associated with abemaciclib have been well documented in clinical trials, it is unknown if adverse events, specifically diarrhea, impact adherence. Food and Drug Administration (FDA) approved abemaciclib to treat adult patients who have HR+ and HER2- advanced or metastatic breast cancer. Nearly 75% of patients with breast cancer have tumors that are hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative. Background: According to the National Cancer Institute, breast cancer is the most common form of cancer in the United States.
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A combination of Scottish ancestry and a mis-spent youth means I have many stories of significant sun-related discomfort.īut now I’m older, wiser and a family man. “The railroad industry is full of the biggest test of character you could ever meet,” he said. “After I saw it and kind of put together what they said they were going to do…I was like, ‘Oh, this is something special.'”ĭespite Johnston’s railroading background, he never imagined he’d work on a passenger train operation, let alone a tourist railway like the cog.īlaise Minor looks out the window of the renovated Broadmoor Manitou and Pikes Peak Cog Railway before heading down on Wednesday, June 30, 2021. Johnston traveled to Colorado Springs to see the operation and the prospects it held. Leaders wanted Johnston to join their project to revamp the railway. “He knew a lot of people, knew all the great places to go,” Johnston said.īut just a year into his life in D.C., The Broadmoor came calling. thanks to the relationships he made there, including his roommate. I was like, ‘What have I done? This is the worst decision I’ve ever made.'”īut Johnston grew to love D.C. “And the first two or three months, I was pulling my hair out. was like a foreign country,” Johnston said. “When I moved out there, being a kid from Oklahoma, D.C. He helped the region reverse its ranking to become the top-rated one for safety.Īfter six years with Union Pacific Railroad, Johnston moved to Washington, D.C., to work as a consultant with RL Banks & Associates, a company specializing in railroad economics and engineering. When Johnston started running trains, he was a part of a region ranked last in safety across the Union Pacific Railroad system. “Fixing problems.”Īnd his skills in problem solving didn’t go unnoticed. “That was always the most exhilarating thing for me,” Johnston said. A train with 30 cars had derailed and he was the one who responsible for cleaning it up. One morning - it was barely 3 a.m. - Johnston was woken by a phone call. “It’s just so unique being out on the railroad and having a whole territory where you’re responsible for all the trains and the crews running the trains,” Johnston said. Johnston spent a year in the training program before he began overseeing hundreds of mile of track. Johnston majored in supply chain management at The University of Oklahoma and entered a management training program with Union Pacific Railroad after he graduated. Johnston grew up in Oklahoma City and as a child he became a train enthusiast, collecting model trains with his dad. That childhood passion led to a career. Johnston, pictured Tuesday, March 15, 2022, helped lead the railway through a $100 million renovation to the tracks, depot and trains. Ted Johnston, who came to The Broadmoor Manitou & Pikes Peak Cog Railway in 2018, has been promoted to general manager. Whilst this list will be familiar to those that have looked at other regions, there are some differences with a handful of games removed and a handful of games added. The WipEout HD Fury expansion pack increases the content of the acclaimed racing game with 8 new tracks, 13 new ship models and 3 new game modes, 2 of which will be available for online play In. Just as a reminder, this list will be updated twice a month by PlayStation. PlayStation Plus Extra will give you access to 400+ PS4/PS5 games whilst PlayStation Plus Deluxe will give you access to 80+ PlayStation Classica and 10+ PS4/PS4 game trials. WipEout Omega Collection brings together all the content from WipEout HD, WipEout HD Fury and WipEout 2048. Wipeout: Omega Collection launches for the PlayStation 4 in the summer of 2017.The new PlayStation Plus launched today and with it came well over 450 games that you can download across two new tiers, PlayStation Plus Extra and PlayStation Plus Deluxe. Completely Remastered for PS4 and PS4 Pro. Many featured modes are playable in local split-screen modes for up to four players, while online matches can accommodate up to eight competitors. A collection of two refurbished titles from a series of futuristic racing games for PlayStation 4. Also on offer are Zone, Tournament, Speed Lap, Time Trial, and Single Race modes from Wipeout HD, along with Zone Battle, Eliminator, and Detonator modes from Wipeout Fury. In wipEout Rush we become the leader of a team, which we lead to victory, gradually unlocking faster cars and various improvements. 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What this awful shipping translates to is this: Higher product price or shipping price. It’s been like this for over a year (edit: 4 years), when I began buying these things by t he dozen. Wait, then why did I rate them two stars? THE SHIPPING! These bins are shipped ASSEMBLED and stacked - taking up about 3x as much space as opposed to stacking them with the lids off. Other reviewers list the actual dimensions, but at least one has an error, so for completeness I will list them again, as taken directly from the Sterilite website: Deep: 14" L x 11" W x 6 1/4" H // 35.6cm L x 27.9cm W x 15.9cm Large: 14" L x 11" W x 3 1/4" H // 35.6cm L x 27.9cm W x 8.3cm H Medium: 11" L x 6 5/8" W x 5 3/8" H // 27.9cm L x 16.8cm W x 13.7cm H Small: 11" L x 6 5/8" W x 2 3/4" H // 27.9cm L x 16.8cm W x 7.0cm H Mini: 6 5/8" L x 5" W x 2 3/4" H // 16.8cm L x 12.7cm W x 7 H. I’d consider a more heavy-duty option for that. (And yes, I do still buy CDs, the reasons for which are outside the scope of this review.) In terms of strength – I would suggest you keep it light to medium, the plastic is sturdy, but I’d hesitate to load them up with heavy items and then stack several up. For the CDs, a couple of cubic inches isn’t such a big loss of space that I can’t handle it for the price, especially given clear top & sides and how much more sturdy this appears to be than some of the more expensive options. There will be a bit of lost space, but it is really hard to find cost-effective storage. The deep… I didn’t realize it when I grabbed these, but this is exactly the right height for a CD! I can fit two rows of CDs with a few tucked in sideways. (If I am going to stack enough papers to fit into that big of a box, it is not only heavy, but I am probably violating whatever organizational principles prompted me to buy it in the first place.) Neither are quite large enough for a file folder to fit – the protruding label of a folder gets in the way. The deeps could also hold papers, but I won’t be using it that way. The large, as others have mentioned, are just the right size for about a ream-sized stack of 8 ½” x 11” or A4 papers, with enough room to spare top & sides to easily access such a pile. (I did not pick up a mini, but based on the dimensions I would guess two would fit side-by-side across the top of the medium/small lid, or four across the large/deep lid.) The medium is about three inches shorter and about one inch taller than typical shoe-box sized boxes, for me this is fine, I like the modularity with the other boxes enough for this to be a good trade-off. Note, however, the mediums are not quite as tall as the deeps, and the smalls are not quite as tall as the larges. Two larges are exactly the same height as one deep, and two smalls are exactly the same height as one medium. As you can see, two medium & smalls fit perfectly on top of a large or deep. On the left are two of the medium topped by one small. I have attached a photo to give you an idea how big these are relative to each other, and to demonstrate the wonderful flexibility these boxes are! Showing on the right from bottom to top, two each are: deep, large, medium and small. I have several boxes for which you flex the lid to snap it on, and these are much easier to take on and off a shelf one-handed without having lids pop off at awkward moments. The sides don’t angle as sharply, and the edges aren't overly -rounded the more rectangular shape looks tidy and gives you a more internal space for the same on-shelf footprint. (See photo.) Because they stack so neatly, I am considering using them to help organize my garage as well. What I really like about these sturdy boxes is how easy it is stack a lot of different sizes neatly. Product Dimensions: 14 x 11 x 6.25 inches Indexed lids allow multiple items to be stacked Identified from any angle, and the tight-clasping latches ensure that the lid The clear base and lid allow contents to be easily The Deep Clip Box is ideal for storing magazines or larger craft items safely Large clip boxes are ideal for storing colored paper, felt, coloring books, and more- Capacity: 1.8.Weight:2.7 kg, Cube: 2.4 cu ft / 0.068 cu m.Tight-clasping latches hold lid securely to base. 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